| Reaction Details |
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 | Report a problem with these data |
| Target | Purinergic receptor P2Y12 |
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| Ligand | BDBM50055818 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1454018 |
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| IC50 | 44±n/a nM |
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| Citation |  Boldron C; Besse A; Bordes MF; Tissandié S; Yvon X; Gau B; Badorc A; Rousseaux T; Barré G; Meneyrol J; Zech G; Nazare M; Fossey V; Pflieger AM; Bonnet-Lignon S; Millet L; Briot C; Dol F; Hérault JP; Savi P; Lassalle G; Delesque N; Herbert JM; Bono F N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist. J Med Chem 57:7293-316 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Purinergic receptor P2Y12 |
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| Name: | Purinergic receptor P2Y12 |
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| Synonyms: | ADP-glucose receptor | ADPG-R | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | SP1999 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39458.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H244 |
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| Residue: | 342 |
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| Sequence: | MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFI
IFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITI
DRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKS
EFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFI
IIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFF
LCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
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| BDBM50055818 |
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| n/a |
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| Name | BDBM50055818 |
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| Synonyms: | CHEMBL3325662 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H38N6O3 |
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| Mol. Mass. | 566.6932 |
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| SMILES | CCCC(=O)c1cnn(c1C)-c1ccc(NC(=O)c2cn(CC(=O)N3CCN(CC3)C3CC3)c3ccc(C)cc23)cc1 |
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| Structure | 
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