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TargetDynamin-1
LigandBDBM50055863
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1458576
IC50 120000±n/a nM
Citation MacGregor KAAbdel-Hamid MKOdell LRChau NWhiting ARobinson PJMcCluskey A Development of quinone analogues as dynamin GTPase inhibitors. Eur J Med Chem 85:191-206 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dynamin-1
Name:Dynamin-1
Synonyms:Dynamin-1
Type:PROTEIN
Mol. Mass.:97411.67
Organism:Homo sapiens (Human)
Description:ChEMBL_1458576
Residue:864
Sequence:
MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPI
NLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSD
LANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQK
DIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKL
QSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGA
RINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKI
REPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLID
IELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKE
YWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY
RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVE
TIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAE
QAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT
PQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAP
PGVPSRSGQASPSRPESPRPPFDL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50055863
n/a
NameBDBM50055863
Synonyms:CHEMBL2252571
TypeSmall organic molecule
Emp. Form.C20H18N2O2
Mol. Mass.318.3691
SMILESO=C1C=C(NCc2ccccc2)C(=O)C=C1NCc1ccccc1 |c:15,t:2|
Structure
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