| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glycogen phosphorylase, liver form |
|---|
| Ligand | BDBM50351158 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1449752 (CHEMBL3378175) |
|---|
| Ki | 4900000±n/a nM |
|---|
| Citation |  Parmenopoulou, V; Kantsadi, AL; Tsirkone, VG; Chatzileontiadou, DS; Manta, S; Zographos, SE; Molfeta, C; Archontis, G; Agius, L; Hayes, JM; Leonidas, DD; Komiotis, D Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-ß-d-glucopyranosylamines. Bioorg Med Chem22:4810-25 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glycogen phosphorylase, liver form |
|---|
| Name: | Glycogen phosphorylase, liver form |
|---|
| Synonyms: | Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN |
|---|
| Type: | Homodimer |
|---|
| Mol. Mass.: | 97153.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Dimers associate into a tetramer to form the enzymatically active phosphorylase A. |
|---|
| Residue: | 847 |
|---|
| Sequence: | MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN
|
|
|
|---|
| BDBM50351158 |
|---|
| n/a |
|---|
| Name | BDBM50351158 |
|---|
| Synonyms: | CHEMBL423707 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H12O6 |
|---|
| Mol. Mass. | 180.1559 |
|---|
| SMILES | OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
