Reaction Details |
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Target | Thromboxane A2 receptor |
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Ligand | BDBM50058026 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1451468 (CHEMBL3364317) |
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IC50 | 54±n/a nM |
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Citation | Ballatore, C; Gay, B; Huang, L; Robinson, KH; James, MJ; Trojanowski, JQ; Lee, VM; Brunden, KR; Smith, AB Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group. Bioorg Med Chem Lett24:4171-5 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane A2 receptor |
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Name: | Thromboxane A2 receptor |
Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
Type: | Enyzme |
Mol. Mass.: | 37445.28 |
Organism: | Homo sapiens (Human) |
Description: | P21731 |
Residue: | 343 |
Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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BDBM50058026 |
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n/a |
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Name | BDBM50058026 |
Synonyms: | CHEMBL3326602 |
Type | Small organic molecule |
Emp. Form. | C20H20ClNO4S |
Mol. Mass. | 405.895 |
SMILES | OC1=C(Cc2cccc(CCNS(=O)(=O)c3ccc(Cl)cc3)c2)CCC1=O |c:1| |
Structure |
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