| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA topoisomerase 4 subunit B |
|---|
| Ligand | BDBM50058509 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1448970 (CHEMBL3376317) |
|---|
| IC50 | 940±n/a nM |
|---|
| Citation |  Yule, IA; Czaplewski, LG; Pommier, S; Davies, DT; Narramore, SK; Fishwick, CW Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: structure based design, synthesis, SAR and antimicrobial activity. Eur J Med Chem86:31-8 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA topoisomerase 4 subunit B |
|---|
| Name: | DNA topoisomerase 4 subunit B |
|---|
| Synonyms: | DNA Topoisomerase IV Subunit B | DNA topoisomerase 4 subunit B (parE) | PARE_ECOLI | nfxD | parE |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 70233.03 |
|---|
| Organism: | Escherichia coli (strain K12) |
|---|
| Description: | n/a |
|---|
| Residue: | 630 |
|---|
| Sequence: | MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILH
ADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVN
ALSKRVEVNVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDETFFDSPRFS
VSRLTHVLKAKAVLCPGVEITFKDEINNTEQRWCYQDGLNDYLAEAVNGLPTLPEKPFIG
NFAGDTEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNI
LPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFILWLNQ
NVQAAELLAEMAISSAQRRMRAAKKVVRKKLTSGPALPGKLADCTAQDLNRTELFLVEGD
SAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSDDLSQL
RYGKICILADADSDGLHIATLLCALFVKHFRALVKHGHVYVALPPLYRIDLGKEVYYALT
EEEKEGVLEQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLTIDDEDDQRTD
AMMDMLLAKKRSEDRRNWLQEKGDMAEIEV
|
|
|
|---|
| BDBM50058509 |
|---|
| n/a |
|---|
| Name | BDBM50058509 |
|---|
| Synonyms: | CHEMBL3329317 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H20N6O3 |
|---|
| Mol. Mass. | 392.4112 |
|---|
| SMILES | CCNC(=O)Nc1cc(Nc2ccc(O)cc2)c(cn1)C(=O)Nc1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
