| Reaction Details |
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 | Report a problem with these data |
| Target | DNA topoisomerase 4 subunit B |
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| Ligand | BDBM50058510 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1448970 (CHEMBL3376317) |
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| IC50 | 42000±n/a nM |
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| Citation |  Yule, IA; Czaplewski, LG; Pommier, S; Davies, DT; Narramore, SK; Fishwick, CW Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: structure based design, synthesis, SAR and antimicrobial activity. Eur J Med Chem86:31-8 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA topoisomerase 4 subunit B |
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| Name: | DNA topoisomerase 4 subunit B |
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| Synonyms: | DNA Topoisomerase IV Subunit B | DNA topoisomerase 4 subunit B (parE) | PARE_ECOLI | nfxD | parE |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 70233.03 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | n/a |
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| Residue: | 630 |
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| Sequence: | MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILH
ADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVN
ALSKRVEVNVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDETFFDSPRFS
VSRLTHVLKAKAVLCPGVEITFKDEINNTEQRWCYQDGLNDYLAEAVNGLPTLPEKPFIG
NFAGDTEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNI
LPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFILWLNQ
NVQAAELLAEMAISSAQRRMRAAKKVVRKKLTSGPALPGKLADCTAQDLNRTELFLVEGD
SAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSDDLSQL
RYGKICILADADSDGLHIATLLCALFVKHFRALVKHGHVYVALPPLYRIDLGKEVYYALT
EEEKEGVLEQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLTIDDEDDQRTD
AMMDMLLAKKRSEDRRNWLQEKGDMAEIEV
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| BDBM50058510 |
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| n/a |
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| Name | BDBM50058510 |
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| Synonyms: | CHEMBL3329319 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N6O4 |
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| Mol. Mass. | 436.4638 |
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| SMILES | CCNC(=O)Nc1cc(Nc2ccc(OC)cc2OC)c(cn1)C(=O)Nc1cccnc1 |
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| Structure | 
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