| Reaction Details |
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 | Report a problem with these data |
| Target | Cruzipain |
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| Ligand | BDBM50058806 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1451533 (CHEMBL3365054) |
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| IC50 | 40±n/a nM |
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| Citation |  Cardoso, MV; de Siqueira, LR; da Silva, EB; Costa, LB; Hernandes, MZ; Rabello, MM; Ferreira, RS; da Cruz, LF; Moreira, DR; Pereira, VR; de Castro, MC; Bernhardt, PV; Leite, AC 2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation. Eur J Med Chem86:48-59 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cruzipain |
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| Name: | Cruzipain |
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| Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
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| Type: | Protein |
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| Mol. Mass.: | 49831.41 |
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| Organism: | Trypanosoma cruzi |
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| Description: | P25779 |
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| Residue: | 467 |
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| Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
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| BDBM50058806 |
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| n/a |
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| Name | BDBM50058806 |
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| Synonyms: | CHEMBL3329519 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N4OS |
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| Mol. Mass. | 324.4 |
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| SMILES | COc1ccc(cc1)-c1csc(N\N=C(/C)c2ccccn2)n1 |
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| Structure | 
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