| Reaction Details |
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 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase |
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| Ligand | BDBM50426014 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1452432 (CHEMBL3362456) |
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| Ki | 12±n/a nM |
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| Citation |  Mandapati, K; Gorla, SK; House, AL; McKenney, ES; Zhang, M; Rao, SN; Gollapalli, DR; Mann, BJ; Goldberg, JB; Cuny, GD; Glomski, IJ; Hedstrom, L Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents. ACS Med Chem Lett5:846-50 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Inosine-5'-monophosphate dehydrogenase |
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| Name: | Inosine-5'-monophosphate dehydrogenase |
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| Synonyms: | AB164_07585 | AB165_01610 | AB166_11280 | AB167_18060 | AB168_06335 | AB169_08740 | AB170_00090 | AB171_19425 | AB893_00065 | ABW01_29210 | ADT20_14595 | ADT21_00085 | BF27_2004 | guaB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52375.32 |
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| Organism: | Bacillus anthracis |
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| Description: | ChEMBL_109471 |
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| Residue: | 487 |
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| Sequence: | MWESKFVKEGLTFDDVLLVPAKSDVLPREVSVKTVLSESLQLNIPLISAGMDTVTEADMA
IAMARQGGLGIIHKNMSIEQQAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRI
SGVPVVNNLDERKLVGIITNRDMRFIQDYSIKISDVMTKEQLITAPVGTTLSEAEKILQK
YKIEKLPLVDNNGVLQGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMTRIDAL
VKASVDAIVLDTAHGHSQGVIDKVKEVRAKYPSLNIIAGNVATAEATKALIEAGANVVKV
GIGPGSICTTRVVAGVGVPQLTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHV
VMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKGSKDRYFQEGNKKLVPEGIEG
RVPYKGPLADTVHQLVGGLRAGMGYCGAQDLEFLRENAQFIRMSGAGLLESHPHHVQITK
EAPNYSL
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| BDBM50426014 |
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| n/a |
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| Name | BDBM50426014 |
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| Synonyms: | CHEMBL2315283 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21N3O3 |
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| Mol. Mass. | 387.4311 |
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| SMILES | Cn1nc(CC(=O)Nc2ccc3oc4CCCCc4c3c2)c2ccccc2c1=O |
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| Structure | 
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