Reaction Details |
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Target | Aurora kinase B |
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Ligand | BDBM50277545 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1460627 (CHEMBL3395868) |
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IC50 | >200±n/a nM |
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Citation | Carry, JC; Clerc, F; Minoux, H; Schio, L; Mauger, J; Nair, A; Parmantier, E; Le Moigne, R; Delorme, C; Nicolas, JP; Krick, A; Abécassis, PY; Crocq-Stuerga, V; Pouzieux, S; Delarbre, L; Maignan, S; Bertrand, T; Bjergarde, K; Ma, N; Lachaud, S; Guizani, H; Lebel, R; Doerflinger, G; Monget, S; Perron, S; Gasse, F; Angouillant-Boniface, O; Filoche-Rommé, B; Murer, M; Gontier, S; Prévost, C; Monteiro, ML; Combeau, C SAR156497, an exquisitely selective inhibitor of aurora kinases. J Med Chem58:362-75 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase B |
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Name: | Aurora kinase B |
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
Type: | Protein |
Mol. Mass.: | 39327.72 |
Organism: | Homo sapiens (Human) |
Description: | Q96GD4 |
Residue: | 344 |
Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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BDBM50277545 |
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n/a |
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Name | BDBM50277545 |
Synonyms: | 4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-ylamino)-2-methoxybenzoic acid | Alisertib | CHEMBL483158 | MLN8237 | US10092556, Example MLN8237 | US9346787, MLN8237 |
Type | Small organic molecule |
Emp. Form. | C27H20ClFN4O4 |
Mol. Mass. | 518.924 |
SMILES | COc1cc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2OC)ccc1C(O)=O |c:11| |
Structure |
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