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TargetAurora kinase B
LigandBDBM50059594
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1460906 (CHEMBL3396726)
IC50 12±n/a nM
Citation Carry, JCClerc, FMinoux, HSchio, LMauger, JNair, AParmantier, ELe Moigne, RDelorme, CNicolas, JPKrick, AAbécassis, PYCrocq-Stuerga, VPouzieux, SDelarbre, LMaignan, SBertrand, TBjergarde, KMa, NLachaud, SGuizani, HLebel, RDoerflinger, GMonget, SPerron, SGasse, FAngouillant-Boniface, OFiloche-Rommé, BMurer, MGontier, SPrévost, CMonteiro, MLCombeau, C SAR156497, an exquisitely selective inhibitor of aurora kinases. J Med Chem58:362-75 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase B
Name:Aurora kinase B
Synonyms:AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:Protein
Mol. Mass.:39327.72
Organism:Homo sapiens (Human)
Description:Q96GD4
Residue:344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50059594
n/a
NameBDBM50059594
Synonyms:CHEMBL3393481
TypeSmall organic molecule
Emp. Form.C24H21N5O4S
Mol. Mass.475.52
SMILESCCOC(=O)c1[nH]cc2C(c3ccc(Sc4nc5cccnc5[nH]4)o3)C3=C(CCCC3=O)Nc12 |t:28|
Structure
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