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TargetHypoxanthine-guanine phosphoribosyltransferase
LigandBDBM50059913
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1461452 (CHEMBL3396536)
Ki 190±n/a nM
Citation Keough, DTHocková, DJaneba, ZWang, THNaesens, LEdstein, MDChavchich, MGuddat, LW Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents. J Med Chem58:827-46 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hypoxanthine-guanine phosphoribosyltransferase
Name:Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:Protein
Mol. Mass.:24579.61
Organism:Homo sapiens (Human)
Description:P00492
Residue:218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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  Blast E-value cutoff:
BDBM50059913
n/a
NameBDBM50059913
Synonyms:CHEMBL3394312
TypeSmall organic molecule
Emp. Form.C12H21N5O8P2
Mol. Mass.425.2714
SMILESOP(O)(=O)CCOCN(CCn1cnc2c1nc[nH]c2=O)CCP(O)(O)=O
Structure
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