| Reaction Details |
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 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
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| Ligand | BDBM50060672 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1462110 (CHEMBL3396817) |
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| IC50 | 8.0±n/a nM |
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| Citation |  Sun, S; Zhang, Z; Pokrovskaia, N; Chowdhury, S; Jia, Q; Chang, E; Khakh, K; Kwan, R; McLaren, DG; Radomski, CC; Ratkay, LG; Fu, J; Dales, NA; Winther, MD Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors. Bioorg Med Chem23:455-65 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stearoyl-CoA desaturase |
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| Name: | Stearoyl-CoA desaturase |
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| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41537.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00767 |
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| Residue: | 359 |
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| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
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| BDBM50060672 |
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| n/a |
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| Name | BDBM50060672 |
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| Synonyms: | CHEMBL3394690 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15F3N6O3S |
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| Mol. Mass. | 464.421 |
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| SMILES | Cc1nc(sc1C(=O)NCc1cccnc1)-n1cnn(Cc2ccc(o2)C(F)(F)F)c1=O |
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| Structure | 
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