| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50060893 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1462197 (CHEMBL3395054) |
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| IC50 | 200±n/a nM |
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| Citation |  Ross, TM; Battista, K; Bignan, GC; Brenneman, DE; Connolly, PJ; Liu, J; Middleton, SA; Orsini, M; Reitz, AB; Rosenthal, DI; Scott, MK; Vaidya, AH A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety. Bioorg Med Chem Lett25:602-6 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42648.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41145 |
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| Residue: | 380 |
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| Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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| BDBM50060893 |
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| n/a |
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| Name | BDBM50060893 |
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| Synonyms: | CHEMBL3394753 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H51FN4O4 |
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| Mol. Mass. | 610.8022 |
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| SMILES | COc1ccc(CCNC[C@H](O)CN2CN(c3ccc(F)cc3)C3(CCN(CC4CCCCCCC4)CC3)C2=O)cc1OC |r| |
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| Structure | 
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