Reaction Details |
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Target | Orexin receptor type 2 |
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Ligand | BDBM120777 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1462307 (CHEMBL3395400) |
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IC50 | 18±n/a nM |
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Citation | Raheem, IT; Breslin, MJ; Bruno, J; Cabalu, TD; Cooke, A; Cox, CD; Cui, D; Garson, S; Gotter, AL; Fox, SV; Harrell, CM; Kuduk, SD; Lemaire, W; Prueksaritanont, T; Renger, JJ; Stump, C; Tannenbaum, PL; Williams, PD; Winrow, CJ; Coleman, PJ Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant. Bioorg Med Chem Lett25:444-50 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Orexin receptor type 2 |
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Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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BDBM120777 |
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n/a |
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Name | BDBM120777 |
Synonyms: | US8710076, E-2 |
Type | Small organic molecule |
Emp. Form. | C24H22FN5O2 |
Mol. Mass. | 431.4622 |
SMILES | C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1ccnc2c(F)cccc12 |r| |
Structure |
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