Reaction Details |
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Target | Growth hormone secretagogue receptor type 1 |
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Ligand | BDBM50061712 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1461883 (CHEMBL3396113) |
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Ki | 28±n/a nM |
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Citation | Orr, ST; Beveridge, R; Bhattacharya, SK; Cameron, KO; Coffey, S; Fernando, D; Hepworth, D; Jackson, MV; Khot, V; Kosa, R; Lapham, K; Loria, PM; McClure, KF; Patel, J; Rose, C; Saenz, J; Stock, IA; Storer, G; von Volkenburg, M; Vrieze, D; Wang, G; Xiao, J; Zhang, Y Evaluation and synthesis of polar aryl- and heteroaryl spiroazetidine-piperidine acetamides as ghrelin inverse agonists. ACS Med Chem Lett6:156-61 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Growth hormone secretagogue receptor type 1 |
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Name: | Growth hormone secretagogue receptor type 1 |
Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) |
Type: | Receptor |
Mol. Mass.: | 41334.57 |
Organism: | Homo sapiens (Human) |
Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. |
Residue: | 366 |
Sequence: | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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BDBM50061712 |
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n/a |
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Name | BDBM50061712 |
Synonyms: | CHEMBL3394206 |
Type | Small organic molecule |
Emp. Form. | C32H37N5O3 |
Mol. Mass. | 539.6679 |
SMILES | COc1ccc(CC(=O)N2CCC3(CN(C3)[C@@H]3CCc4cc(ccc34)-c3cc(C)ncn3)CC2)c(NC(C)=O)c1 |r| |
Structure |
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