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TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain
LigandBDBM50014846
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1462872 (CHEMBL3399784)
IC50 1700±n/a nM
Citation Suman, PMurthy, TRRajkumar, KSrikanth, DDayakar, ChKishor, CAddlagatta, AKalivendi, SVRaju, BC Synthesis and structure-activity relationships of pyridinyl-1H-1,2,3-triazolyldihydroisoxazoles as potent inhibitors of tubulin polymerization. Eur J Med Chem90:603-19 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain
Name:Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain
Synonyms:Tubulin
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 1443869
Components:This complex has 3 components.
Component 1
Name:Similar to alpha-tubulin isoform 1
Synonyms:Similar to alpha-tubulin isoform 1
Type:PROTEIN
Mol. Mass.:10383.05
Organism:Bos taurus
Description:ChEMBL_104716
Residue:99
Sequence:
CVSASPSTLARLVSRSAMPAGSSTAWNTAFSPMARCQVTKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRSSSTLSSSSQAKKMP
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Component 2
Name:Similar to alpha-tubulin isoform 1
Synonyms:Tubulin
Type:PROTEIN
Mol. Mass.:9422.48
Organism:Bos taurus
Description:EBI_18002
Residue:84
Sequence:
PSPQVSTAVVEPYNSILTTKHLEHSDCFMVDNEAIYDICRRNLDIERPTTRNLNRLMSQI
VSSITASLRFDGALTVDLTDVQTS
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Component 3
Name:Tubulin beta-2B chain
Synonyms:TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:PROTEIN
Mol. Mass.:49932.38
Organism:Bos taurus
Description:ChEMBL_211651
Residue:445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
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BDBM50014846
n/a
NameBDBM50014846
Synonyms:(S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide | (S)-colchicine | 7alphaH-colchicine | CHEMBL107 | COLCHICINE | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide | colchicina | colchicinum
TypeSmall organic molecule
Emp. Form.C22H25NO6
Mol. Mass.399.437
SMILESCOc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: