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TargetKallikrein-1
LigandBDBM50063582
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1463563 (CHEMBL3398781)
Ki>30000±n/a nM
Citation Pinto, DJSmallheer, JMCorte, JRAustin, EJWang, CFang, TSmith, LMRossi, KARendina, ARBozarth, JMZhang, GWei, ARamamurthy, VSheriff, SMyers, JEMorin, PELuettgen, JMSeiffert, DAQuan, MLWexler, RR Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties. Bioorg Med Chem Lett25:1635-42 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kallikrein-1
Name:Kallikrein-1
Synonyms:KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein
Type:Enzyme
Mol. Mass.:28874.69
Organism:Homo sapiens (Human)
Description:P06870
Residue:262
Sequence:
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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  Blast E-value cutoff:
BDBM50063582
n/a
NameBDBM50063582
Synonyms:CHEMBL3398642
TypeSmall organic molecule
Emp. Form.C29H25ClN8O3
Mol. Mass.569.014
SMILESCOC(=O)Nc1ccc(cc1)-c1c[nH]c(n1)[C@H](Cc1ccccc1)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1 |r|
Structure
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