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TargetHistone-lysine N-methyltransferase KMT5C
LigandBDBM50009672
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1463680 (CHEMBL3399139)
IC50 10000±n/a nM
Citation Kung, PP; Huang, B; Zehnder, L; Tatlock, J; Bingham, P; Krivacic, C; Gajiwala, K; Diehl, W; Yu, X; Maegley, KA SAH derived potent and selective EZH2 inhibitors. Bioorg Med Chem Lett25:1532-7 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone-lysine N-methyltransferase KMT5C
Name:Histone-lysine N-methyltransferase KMT5C
Synonyms:Histone-lysine N-methyltransferase SUV420H2 | KMT5C | KMT5C_HUMAN | Lysine N-methyltransferase 5C | Protein lysine methyltransferase SUV4-20H2 (SUV4-20H2) | SUV420H2 | Su(var)4-20 homolog 2 | Suppressor of variegation 4-20 homolog 2 | Suv4-20h2
Type:Enzyme
Mol. Mass.:52147.69
Organism:Homo sapiens (Human)
Description:Q86Y97
Residue:462
Sequence:
MGPDRVTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPPLRRQQHLRSALETFLRQRD
LEAAYRALTLGGWTARYFQSRGPRQEAALKTHVYRYLRAFLPESGFTILPCTRYSMETNG
AKIVSTRAWKKNEKLELLVGCIAELREADEGLLRAGENDFSIMYSTRKRSAQLWLGPAAF
INHDCKPNCKFVPADGNAACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCECHTCERKGEG
AFRTRPREPALPPRPLDKYQLRETKRRLQQGLDSGSRQGLLGPRACVHPSPLRRDPFCAA
CQPLRLPACSARPDTSPLWLQWLPQPQPRVRPRKRRRPRPRRAPVLSTHHAARVSLHRWG
GCGPHCRLRGEALVALGQPPHARWAPQQDWHWARRYGLPYVVRVDLRRLAPAPPATPAPA
GTPGPILIPKQALAFAPFSPPKRLRLVVSHGSIDLDVGGEEL
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  Blast E-value cutoff:
BDBM50009672
n/a
NameBDBM50009672
Synonyms:AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocysteine | S-(5'-deoxyadenosin-5'-yl)-L-homocysteine | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl]-L-homocysteine | S-adenosyl-L-homocysteine | SAH | US8895245, S-Adenosyl-L-homocysteine (SAH) | US9175331, 1 | US9333217, S-Adenosyl-L-homocysteine (SAH)
TypeSmall organic molecule
Emp. Form.C14H20N6O5S
Mol. Mass.384.411
SMILESN[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Structure
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