| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase EZH1 |
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| Ligand | BDBM50063670 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1463671 (CHEMBL3399058) |
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| IC50 | 2100±n/a nM |
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| Citation |  Kung, PP; Huang, B; Zehnder, L; Tatlock, J; Bingham, P; Krivacic, C; Gajiwala, K; Diehl, W; Yu, X; Maegley, KA SAH derived potent and selective EZH2 inhibitors. Bioorg Med Chem Lett25:1532-7 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase EZH1 |
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| Name: | Histone-lysine N-methyltransferase EZH1 |
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| Synonyms: | ENX-2 | EZH1 | EZH1_HUMAN | Enhancer of zeste homolog 1 | Enhancer of zeste homolog 1 (EZH1) | Histone-lysine N-methyltransferase EZH1 | KIAA0388 |
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| Type: | Protein |
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| Mol. Mass.: | 85285.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92800 |
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| Residue: | 747 |
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| Sequence: | MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAI
ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR
RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR
RRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP
QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK
LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT
QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV
SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD
KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG
EELFFDYRYSQADALKYVGIERETDVL
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| BDBM50063670 |
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| n/a |
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| Name | BDBM50063670 |
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| Synonyms: | CHEMBL3397332 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29N9O4S |
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| Mol. Mass. | 539.61 |
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| SMILES | N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(=O)NCc1cc([nH]n1)-c1ccccc1 |r| |
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| Structure | 
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