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TargetThyroid hormone receptor beta
LigandBDBM50063692
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1463692 (CHEMBL3399151)
Ki 1.1±n/a nM
Citation Burkholder, TPCunningham, BEClayton, JRLander, PABrown, MLDoti, RADurst, GLMontrose-Rafizadeh, CKing, COsborne, HEAmos, RMZink, RWStramm, LEBurris, TPCardona, GKonkol, DLReidy, CChriste, MEGenin, MJ Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptorß agonists. Bioorg Med Chem Lett25:1377-80 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thyroid hormone receptor beta
Name:Thyroid hormone receptor beta
Synonyms:ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta
Type:Receptor
Mol. Mass.:52793.62
Organism:Homo sapiens (Human)
Description:Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1.
Residue:461
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50063692
n/a
NameBDBM50063692
Synonyms:CHEMBL3397334
TypeSmall organic molecule
Emp. Form.C21H23NO4
Mol. Mass.353.4116
SMILESCC(C)c1cc(Cn2c(C)cc3cc(OCC(O)=O)ccc23)ccc1O
Structure
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