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TargetThyroid hormone receptor alpha
LigandBDBM50063755
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1463693 (CHEMBL3399152)
Ki 0.510000±n/a nM
Citation Burkholder, TPCunningham, BEClayton, JRLander, PABrown, MLDoti, RADurst, GLMontrose-Rafizadeh, CKing, COsborne, HEAmos, RMZink, RWStramm, LEBurris, TPCardona, GKonkol, DLReidy, CChriste, MEGenin, MJ Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptorß agonists. Bioorg Med Chem Lett25:1377-80 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thyroid hormone receptor alpha
Name:Thyroid hormone receptor alpha
Synonyms:C-erbA-alpha | EAR-7 | EAR7 | ERBA1 | NR1A1 | Nuclear receptor subfamily 1 group A member 1 | THA_HUMAN | THRA | THRA1 | THRA2 | Thyroid Hormone Receptor (TR-alpha) | Thyroid hormone receptor | Thyroid hormone receptor alpha | Thyroid hormone receptor apha | c-erbA-1
Type:Receptor
Mol. Mass.:54818.00
Organism:Homo sapiens (Human)
Description:Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRalpha 1.
Residue:490
Sequence:
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
EDLAGNAASP
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  Blast E-value cutoff:
BDBM50063755
n/a
NameBDBM50063755
Synonyms:CHEMBL3397341
TypeSmall organic molecule
Emp. Form.C21H22ClNO4
Mol. Mass.387.857
SMILESCC(C)c1cc(Cn2cc(C)c3cc(OCC(O)=O)cc(Cl)c23)ccc1O
Structure
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