Reaction Details |
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Target | Glycogen synthase kinase-3 beta |
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Ligand | BDBM50064150 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1464792 (CHEMBL3404147) |
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IC50 | 16±n/a nM |
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Citation | Fukunaga, K; Sakai, D; Watanabe, K; Nakayama, K; Kohara, T; Tanaka, H; Sunada, S; Nabeno, M; Okamoto, M; Saito, K; Eguchi, J; Mori, A; Tanaka, S; Inazawa, K; Horikawa, T Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3ß inhibitors for Alzheimer's disease. Bioorg Med Chem Lett25:1086-91 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen synthase kinase-3 beta |
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Name: | Glycogen synthase kinase-3 beta |
Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
Type: | Enzyme |
Mol. Mass.: | 46756.38 |
Organism: | Homo sapiens (Human) |
Description: | P49841 |
Residue: | 420 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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BDBM50064150 |
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n/a |
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Name | BDBM50064150 |
Synonyms: | CHEMBL3401125 |
Type | Small organic molecule |
Emp. Form. | C16H19FN4O2 |
Mol. Mass. | 318.3461 |
SMILES | C[C@@H]1OCCN([C@@H]1C)c1nc(cc(=O)n1C)-c1ccncc1F |r| |
Structure |
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