| Reaction Details |
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 | Report a problem with these data |
| Target | Cystathionine beta-synthase |
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| Ligand | BDBM50064265 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1464805 (CHEMBL3404160) |
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| IC50 | 170000±n/a nM |
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| Citation |  Thorson, MK; Van Wagoner, RM; Harper, MK; Ireland, CM; Majtan, T; Kraus, JP; Barrios, AM Marine natural products as inhibitors of cystathionine beta-synthase activity. Bioorg Med Chem Lett25:1064-6 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Cystathionine beta-synthase |
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| Name: | Cystathionine beta-synthase |
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| Synonyms: | Beta-thionase | CBS | CBS_HUMAN | Serine sulfhydrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60586.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109567 |
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| Residue: | 551 |
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| Sequence: | MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPA
SESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKD
RISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDV
LRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEI
LQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTT
YEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKA
AQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLS
APLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVG
KVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLL
NFVAAQERDQK
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| BDBM50064265 |
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| n/a |
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| Name | BDBM50064265 |
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| Synonyms: | CHEMBL1956777 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H8N2OS |
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| Mol. Mass. | 204.248 |
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| SMILES | O=C1NC(=S)N\C1=C/c1ccccc1 |
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| Structure | 
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