Reaction Details |
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Target | Calcium release-activated calcium channel protein 1 |
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Ligand | BDBM50064640 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1465032 (CHEMBL3405048) |
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IC50 | 440±n/a nM |
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Citation | Esteve, C; González, J; Gual, S; Vidal, L; Alzina, S; Sentellas, S; Jover, I; Horrillo, R; De Alba, J; Miralpeix, M; Tarrasón, G; Vidal, B Discovery of 7-azaindole derivatives as potent Orai inhibitors showing efficacy in a preclinical model of asthma. Bioorg Med Chem Lett25:1217-22 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Calcium release-activated calcium channel protein 1 |
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Name: | Calcium release-activated calcium channel protein 1 |
Synonyms: | CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A |
Type: | Protein |
Mol. Mass.: | 32676.63 |
Organism: | Homo sapiens (Human) |
Description: | Q96D31 |
Residue: | 301 |
Sequence: | MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSY
SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLL
IAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFST
VIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIAST
TIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHY
A
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BDBM50064640 |
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n/a |
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Name | BDBM50064640 |
Synonyms: | CHEMBL3403753 |
Type | Small organic molecule |
Emp. Form. | C20H15ClFN3O2 |
Mol. Mass. | 383.803 |
SMILES | COc1cc(OC)c(cn1)-c1cnc2[nH]c(cc2c1)-c1c(F)cccc1Cl |
Structure |
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