| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase BTK |
|---|
| Ligand | BDBM50064873 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1465191 (CHEMBL3406075) |
|---|
| IC50 | 1100±n/a nM |
|---|
| Citation |  Young, WB; Barbosa, J; Blomgren, P; Bremer, MC; Crawford, JJ; Dambach, D; Gallion, S; Hymowitz, SG; Kropf, JE; Lee, SH; Liu, L; Lubach, JW; Macaluso, J; Maciejewski, P; Maurer, B; Mitchell, SA; Ortwine, DF; Di Paolo, J; Reif, K; Scheerens, H; Schmitt, A; Sowell, CG; Wang, X; Wong, H; Xiong, JM; Xu, J; Zhao, Z; Currie, KS Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834. Bioorg Med Chem Lett25:1333-7 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase BTK |
|---|
| Name: | Tyrosine-protein kinase BTK |
|---|
| Synonyms: | ATK | Agammaglobulinemia tyrosine kinase | B-cell progenitor kinase | BTK_MOUSE | Bpk | Bruton tyrosine kinase | Btk | Kinase EMB |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 76447.19 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_108319 |
|---|
| Residue: | 659 |
|---|
| Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVIPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPTAAPISTTELKKVVALYDYMPMNANDLQLRKGEE
YFILEESNLPWWRARDKNGQEGYIPSNYITEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGEPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSKQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADERPSFKILLSNILDVMDEES
|
|
|
|---|
| BDBM50064873 |
|---|
| n/a |
|---|
| Name | BDBM50064873 |
|---|
| Synonyms: | CHEMBL3401271 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H37N5O4Si |
|---|
| Mol. Mass. | 595.7635 |
|---|
| SMILES | Cc1c(NC(=O)c2ccc(cc2)[Si](C)(C)C)cccc1-c1cn(C)c(=O)c(Nc2ccc(cc2)C(=O)N2CCOCC2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
