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TargetInterleukin-8 receptors, CXCR2
LigandBDBM50065267
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1465563
IC50 10.0±n/a nM
Citation Austin RPBennion CBonnert RVCheema LCook ARCox RJEbden MRGaw AGrime KMeghani PNicholls DPhillips CSmith NSteele JStonehouse JP Discovery and evaluation of a novel monocyclic series of CXCR2 antagonists. Bioorg Med Chem Lett 25:1616-20 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Interleukin-8 receptors, CXCR2
Name:Interleukin-8 receptors, CXCR1/CXCR2
Synonyms:C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | Interleukin-8 receptor B
Type:Protein
Mol. Mass.:40767.88
Organism:Homo sapiens (Human)
Description:P25025
Residue:360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
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  Blast E-value cutoff:
BDBM50065267
n/a
NameBDBM50065267
Synonyms:CHEMBL3403840
TypeSmall organic molecule
Emp. Form.C15H17F3N4O3S2
Mol. Mass.422.446
SMILESC[C@H](CO)Nc1cc(NS(=O)(=O)C(F)(F)F)nc(SCc2ccccc2)n1 |r|
Structure
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