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TargetCathepsin E
LigandBDBM50065428
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1465919 (CHEMBL3406747)
Ki 1100±n/a nM
Citation McKittrick, BACaldwell, JPBara, TBoykow, GChintala, MClader, JCzarniecki, MCourneya, BDuffy, RFleming, LGiessert, RGreenlee, WJHeap, CHong, LHuang, YIserloh, UJosien, HKhan, TKorfmacher, WLiang, XMazzola, RMitra, SMoore, KOrth, PRajagopalan, MRoy, SSakwa, SStrickland, CVaccaro, HVoigt, JWang, HWong, JZhang, RZych, A Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors. Bioorg Med Chem Lett25:1592-6 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin E
Name:Cathepsin E
Synonyms:3.4.23.34 | CATE_HUMAN | CTSE | Cathepsin E form I | Cathepsin E form II
Type:Enzyme
Mol. Mass.:43298.99
Organism:Homo sapiens (Human)
Description:P14091
Residue:396
Sequence:
MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESC
SMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRF
QPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAE
FDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSH
FSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNA
IGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDI
HPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50065428
n/a
NameBDBM50065428
Synonyms:CHEMBL3401350
TypeSmall organic molecule
Emp. Form.C24H29FN4O2
Mol. Mass.424.5111
SMILESCC(C)[C@]1(C)CC(=O)N(Cc2cc(F)cc(c2)C(=O)N[C@@H](C)c2ccccc2)C(=N)N1 |r|
Structure
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