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TargetSphingosine 1-Phosphate Receptor 2
LigandBDBM50065625
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1463948
IC50 1300±n/a nM
Citation Kusumi KShinozaki KKanaji TKurata HNaganawa AOtsuki KMatsushita TSekiguchi TKakuuchi ASeko T Discovery of novel S1P2 antagonists. Part 1: discovery of 1,3-bis(aryloxy)benzene derivatives. Bioorg Med Chem Lett 25:1479-82 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-Phosphate Receptor 2
Name:Sphingosine 1-phosphate receptor Edg-5/Sphingosine 1-phosphate receptor Edg-3
Synonyms:S1P2 | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:38883.16
Organism:Homo sapiens (Human)
Description:Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.
Residue:353
Sequence:
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS
TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVL
RPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
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  Blast E-value cutoff:
BDBM50065625
n/a
NameBDBM50065625
Synonyms:CHEMBL3400192
TypeSmall organic molecule
Emp. Form.C25H34N2O3
Mol. Mass.410.5491
SMILESCCC(CC)CC1(O)CCN(CC1)C(=O)Nc1cccc(Oc2cccc(C)c2)c1
Structure
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