| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyphenol oxidase 2 |
|---|
| Ligand | BDBM50066275 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1465619 (CHEMBL3404921) |
|---|
| Ki | 2620±n/a nM |
|---|
| Citation |  Radhakrishnan, SK; Shimmon, RG; Conn, C; Baker, AT Azachalcones: a new class of potent polyphenol oxidase inhibitors. Bioorg Med Chem Lett25:1753-6 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyphenol oxidase 2 |
|---|
| Name: | Polyphenol oxidase 2 |
|---|
| Synonyms: | Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 63923.66 |
|---|
| Organism: | Agaricus bisporus (Common mushroom) |
|---|
| Description: | O42713 |
|---|
| Residue: | 556 |
|---|
| Sequence: | MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
|
|
|
|---|
| BDBM50066275 |
|---|
| n/a |
|---|
| Name | BDBM50066275 |
|---|
| Synonyms: | CHEMBL3401548 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H13NO2 |
|---|
| Mol. Mass. | 227.2585 |
|---|
| SMILES | OC(\C=C\c1ccccn1)c1ccccc1O |
|---|
| Structure | 
|
|---|
Search and Browse
