| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteinyl leukotriene receptor 2 |
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| Ligand | BDBM50033085 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1466141 (CHEMBL3404759) |
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| IC50 | 2.5±n/a nM |
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| Citation |  Itadani, S; Takahashi, S; Ima, M; Sekiguchi, T; Aratani, Y; Egashira, H; Matsumura, N; Inoue, A; Yonetomi, Y; Fujita, M; Nakayama, Y; Takeuchi, J Discovery of a potent, orally available dual CysLT1 and CysLT2 antagonist with dicarboxylic acid. Bioorg Med Chem23:2079-97 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteinyl leukotriene receptor 2 |
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| Name: | Cysteinyl leukotriene receptor 2 |
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| Synonyms: | CLTR2_HUMAN | CYSLT2 | CYSLT2R | CYSLTR2 | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 2 | Leukotriene Cysteinyl 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39657.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Leukotriene Cysteinyl 2 CYSLTR2 HUMAN::Q9NS75 |
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| Residue: | 346 |
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| Sequence: | MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSI
YVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYV
NMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQ
NGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRV
SHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACF
NPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
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| BDBM50033085 |
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| n/a |
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| Name | BDBM50033085 |
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| Synonyms: | CHEMBL3342955 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H32N2O7 |
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| Mol. Mass. | 532.5843 |
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| SMILES | OC(=O)CCCN1CC(Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc12)C(O)=O |
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| Structure | 
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