Ki Summary

Reaction Details

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Target

High affinity choline transporter 1

Ligand

BDBM87577

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1464243 (CHEMBL3404110)

IC50

4470±n/a nM

Citation

Bollinger, SR; Engers, DW; Ennis, EA; Wright, J; Locuson, CW; Lindsley, CW; Blakely, RD; Hopkins, CR Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter. Bioorg Med Chem Lett25:1757-60 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

High affinity choline transporter 1

Name:

High affinity choline transporter 1

Synonyms:

CHT1 | High-affinity choline transporter | SC5A7_HUMAN | SLC5A7 | high affinity choline transporter 1

Type:

PROTEIN

Mol. Mass.:

63194.33

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1464247

Residue:

580

Sequence:

MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTA
TWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQ
IYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGG
LYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSW
LDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDW
NQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFA
RNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQ
LLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFK
TLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLD
ELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ

BDBM87577

n/a

Name

BDBM87577

Synonyms:

3-[(1-isopropyl-4-piperidyl)oxy]-4-methoxy-N-(1-methyl-2-pyrazin-2-yl-ethyl)benzamide | 4-methoxy-3-(1-propan-2-ylpiperidin-4-yl)oxy-N-(1-pyrazin-2-ylpropan-2-yl)benzamide | 4-methoxy-3-[(1-propan-2-yl-4-piperidinyl)oxy]-N-[1-(2-pyrazinyl)propan-2-yl]benzamide | MLS001105317 | SMR000659568 | cid_24793875

Type

Small organic molecule

Emp. Form.

C23H32N4O3

Mol. Mass.

412.5252

SMILES

COc1ccc(cc1OC1CCN(CC1)C(C)C)C(=O)NC(C)Cc1cnccn1

Structure