Reaction Details | |||
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Target | cAMP-dependent protein kinase catalytic subunit alpha | ||
Ligand | BDBM50067539 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1465695 (CHEMBL3405456) | ||
Ki | >4000±n/a nM | ||
Citation | Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg Med Chem Lett25:1990-4 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-dependent protein kinase catalytic subunit alpha | |||
Name: | cAMP-dependent protein kinase catalytic subunit alpha | ||
Synonyms: | KAPCA_HUMAN | PKA C-alpha | PKACA | PRKACA | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase, alpha-catalytic subunit | ||
Type: | Enzyme Catalytic Subunit | ||
Mol. Mass.: | 40598.73 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 351 | ||
Sequence: |
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BDBM50067539 | |||
n/a | |||
Name | BDBM50067539 | ||
Synonyms: | CHEMBL3401989 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H21F2N7O | ||
Mol. Mass. | 437.4452 | ||
SMILES | Cc1nnc(o1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:6.6,wD:13.16,(7.33,-.85,;6.11,-.67,;5.4,.7,;3.88,.44,;3.68,-1.07,;5.04,-1.77,;2.26,-1.79,;2.12,-3.4,;.73,-4.07,;-.57,-3.2,;-.48,-1.66,;.83,-1.64,;.86,-3.35,;.93,-.96,;.98,.59,;-.32,1.41,;-.27,2.95,;-1.57,3.76,;-2.93,3.04,;-2.99,1.5,;-1.68,.68,;-1.73,-.55,;-1.52,5.3,;-2.72,6.2,;-2.2,7.65,;-.67,7.61,;.39,8.73,;1.9,8.35,;2.32,6.87,;3.52,6.58,;1.24,5.75,;-.25,6.13,)| | ||
Structure |