Ki Summary

Reaction Details

Report a problem with these data

Target

cAMP-dependent protein kinase (PKA)

Ligand

BDBM50067531

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1465695

490±n/a nM

Citation

Boyd MJ; Bandarage UK; Bennett H; Byrn RR; Davies I; Gu W; Jacobs M; Ledeboer MW; Ledford B; Leeman JR; Perola E; Wang T; Bennani Y; Clark MP; Charifson PS Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg Med Chem Lett 25:1990-4 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

cAMP-dependent protein kinase (PKA)

Name:

cAMP-dependent protein kinase (PKA)

Synonyms:

PKA C-alpha | cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase, alpha-catalytic subunit

Type:

Enzyme Catalytic Subunit

Mol. Mass.:

40598.73

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

351

Sequence:

MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVML
VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF

BDBM50067531

n/a

Name

BDBM50067531

Synonyms:

CHEMBL3401983

Type

Small organic molecule

Emp. Form.

C19H20F2N6O2S

Mol. Mass.

434.463

SMILES

NS(=O)(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:11.13,wD:4.3,(1.06,4.97,;1.05,3.73,;1.93,3.21,;2.12,4.34,;-.29,2.98,;-1.7,3.76,;-3.03,2.98,;-3.03,1.41,;-1.7,.63,;-.96,1.7,;-2.37,2.68,;-.33,1.41,;.98,.59,;2.34,1.32,;2.39,2.86,;3.74,3.59,;5.05,2.78,;5.01,1.24,;3.65,.51,;3.61,-.72,;3.79,5.12,;5.05,5.94,;4.63,7.43,;3.1,7.48,;2.12,8.67,;.58,8.39,;.06,6.95,;-1.15,6.73,;1.06,5.75,;2.58,6.04,)|

Structure