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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Vascular endothelial growth factor receptor 2 | ||
| Ligand | BDBM50067535 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1465693 (CHEMBL3405454) | ||
| Ki | >4000±n/a nM | ||
| Citation |  Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg Med Chem Lett25:1990-4 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Vascular endothelial growth factor receptor 2 | |||
| Name: | Vascular endothelial growth factor receptor 2 | ||
| Synonyms: | CD_antigen=CD309 | FLK1 | Fetal liver kinase 1 (FLK-1) | Flk-1/KDR | KDR | Kinase Insert Domain Receptor | Protein-tyrosine kinase receptor Flk-1 | VEGFR kinase (KDR) | VEGFR-2 | VEGFR-2 (KDR) | VEGFR2 | VGFR2_HUMAN | Vascular Endothelial Growth Factor Receptor Kinase 2 | Vascular endothelial growth factor receptor (VEGFR-2) | Vascular endothelial growth factor receptor 2 (KDR) | Vascular endothelial growth factor receptor 2 (VEGFR-2) | Vascular endothelial growth factor receptor 2 (VEGFR2) | Vascular endothelial growth factor receptor 2 precursor (VEGFR-2) | Vascular endothelial growth factor receptor-2 (VEGFR-2) | ||
| Type: | Receptor Tyrosine Kinase | ||
| Mol. Mass.: | 151510.97 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P35968 | ||
| Residue: | 1356 | ||
| Sequence: |
| ||
| BDBM50067535 | |||
| n/a | |||
| Name | BDBM50067535 | ||
| Synonyms: | CHEMBL3401986 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H22F2N6O | ||
| Mol. Mass. | 412.4358 | ||
| SMILES | CNC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:11.13,wD:4.3,(3.45,3.56,;2.38,2.95,;1.05,3.73,;1.06,4.97,;-.29,2.98,;-1.7,3.76,;-3.03,2.98,;-3.03,1.41,;-1.7,.63,;-.96,1.7,;-2.37,2.68,;-.33,1.41,;.98,.59,;.93,-.95,;-.42,-1.67,;-.48,-3.21,;.83,-4.02,;2.19,-3.3,;2.24,-1.76,;3.33,-1.18,;-1.83,-3.93,;-2.01,-5.43,;-3.53,-5.71,;-4.26,-4.36,;-5.76,-4.01,;-6.19,-2.51,;-5.12,-1.4,;-5.47,-.22,;-3.61,-1.77,;-3.19,-3.25,)| | ||
| Structure | 
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