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TargetProtease
LigandBDBM50067593
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1466205
Temperature298.15±n/a K
IC50 0.880000±n/a nM
Commentsextracted
Citation Yang ZHBai XGZhou LWang JXLiu HTWang YC Synthesis and biological evaluation of novel HIV-1 protease inhibitors using tertiary amine as P2-ligands. Bioorg Med Chem Lett 25:1880-3 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protease
Name:Protease
Synonyms:n/a
Type:Enzyme
Mol. Mass.:10904.79
Organism:Human immunodeficiency virus 1 (HIV-1)
Description:Q9YQ12
Residue:99
Sequence:
PQITLWQRPFVTIKIEGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIVIEICGKKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50067593
n/a
NameBDBM50067593
Synonyms:CHEBI:44032 | Crixivan | INDINAVIR | Indinavir | L-735524 | MK-639
TypeSmall organic molecule
Emp. Form.C36H47N5O4
Mol. Mass.613.7895
SMILESCC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12 |r|
Structure
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