| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50068115 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1464059 (CHEMBL3406244) |
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| Ki | 48±n/a nM |
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| Citation |  Yildirim, A; Atmaca, U; Keskin, A; Topal, M; Çelik, M; Gülçin, I; Supuran, CT N-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes I and II. Bioorg Med Chem23:2598-605 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50068115 |
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| n/a |
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| Name | BDBM50068115 |
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| Synonyms: | CHEMBL3402248 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H17Cl6NO5S |
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| Mol. Mass. | 632.168 |
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| SMILES | Cc1ccc(cc1)S(=O)(=O)NC(=O)C1[C@H](C(=O)OCc2ccccc2)[C@@]2(Cl)C(Cl)=C(Cl)[C@@]1(Cl)C2(Cl)Cl |r,t:30,TLB:15:14:27.29:33,THB:11:13:27.29:33,30:29:33:13.14,28:27:33:13.14| |
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| Structure | 
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