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TargetAlkaline phosphatase, tissue-nonspecific isozyme
LigandBDBM50068229
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1464323 (CHEMBL3404590)
Ki 60±n/a nM
Citation Al-Rashida, MEjaz, SAAli, SShaukat, AHamayoun, MAhmed, MIqbal, J Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase: Structure activity relationship and molecular modelling studies. Bioorg Med Chem23:2435-44 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alkaline phosphatase, tissue-nonspecific isozyme
Name:Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:ALPL | AP-TNAP | Alkaline phosphatase liver/bone/kidney isozyme | Alkaline phosphatase, tissue-nonspecific isozyme | PPBT_BOVIN | TNSALP | Tissue non-specific alkaline phosphatase (TNAP)
Type:Protein
Mol. Mass.:57195.60
Organism:Bos taurus (Cattle)
Description:P09487
Residue:524
Sequence:
MISPFLLLAIGTCFASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIEVIMGGGRKYMFPKNRTDVEYELDE
KARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHSVDYLLGLFEPGDMQYELN
RNNATDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIG
QAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYI
PHVMAYAACIGANRDHCASASSSGSPSPGPLLLLLALLPLGSLF
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  Blast E-value cutoff:
BDBM50068229
n/a
NameBDBM50068229
Synonyms:CHEMBL3403327
TypeSmall organic molecule
Emp. Form.C12H11FN2O4S2
Mol. Mass.330.355
SMILESNS(=O)(=O)c1cccc(NS(=O)(=O)c2ccc(F)cc2)c1
Structure
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