| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Ligand | BDBM50068286 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1464338 (CHEMBL3404605) |
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| IC50 | 1.4±n/a nM |
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| Citation |  Endo, Y; Kawai, K; Asano, T; Amano, S; Asanuma, Y; Sawada, K; Onodera, Y; Ueo, N; Takahashi, N; Sonoda, Y; Kamei, N; Irie, T 2-(Isopropylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as selective phosphodiesterase 7 inhibitors with potent in vivo efficacy. Bioorg Med Chem Lett25:1910-4 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55514.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13946 |
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| Residue: | 482 |
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| Sequence: | MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
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| BDBM50068286 |
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| n/a |
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| Name | BDBM50068286 |
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| Synonyms: | CHEMBL3403373 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27N5O2S |
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| Mol. Mass. | 425.547 |
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| SMILES | CCn1c(NC(C)C)nc2c(csc2c1=O)C1CCN(C1)C(=O)c1ncccc1C |
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| Structure | 
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