| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM50068306 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1466466 (CHEMBL3406576) |
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| IC50 | 20±n/a nM |
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| Citation |  Wieckowska, A; Wieckowski, K; Bajda, M; Brus, B; Salat, K; Czerwinska, P; Gobec, S; Filipek, B; Malawska, B Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors withß-amyloid anti-aggregation properties and beneficial effects on memory in vivo. Bioorg Med Chem23:2445-57 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACES_ELEEL | Acetylcholinesterase (AChE) | Acetylcholinesterase (EeAChE) | ache |
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| Type: | Enzyme |
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| Mol. Mass.: | 71812.79 |
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| Organism: | Electrophorus electricus (Electric eel) |
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| Description: | n/a |
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| Residue: | 633 |
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| Sequence: | MKILDALLFPVIFIMFFIHLSIAQTDPELTIMTRLGQVQGTRLPVPDRSHVIAFLGIPFA
EPPLGKMRFKPPEPKKPWNDVFDARDYPSACYQYVDTSYPGFSGTEMWNPNRMMSEDCLY
LNVWVPATPRPHNLTVMVWIYGGGFYSGSSSLDVYDGRYLAHSEKVVVVSMNYRVSAFGF
LALNGSAEAPGNVGLLDQRLALQWVQDNIHFFGGNPKQVTIFGESAGAASVGMHLLSPDS
RPKFTRAILQSGVPNGPWRTVSFDEARRRAIKLGRLVGCPDGNDTDLIDCLRSKQPQDLI
DQEWLVLPFSGLFRFSFVPVIDGVVFPDTPEAMLNSGNFKDTQILLGVNQNEGSYFLIYG
APGFSKDNESLITREDFLQGVKMSVPHANEIGLEAVILQYTDWMDEDNPIKNREAMDDIV
GDHNVVCPLQHFAKMYAQYSILQGQTGTASQGNLGWGNSGSASNSGNSQVSVYLYMFDHR
ASNLVWPEWMGVIHGYEIEFVFGLPLEKRLNYTLEEEKLSRRMMKYWANFARTGNPNINV
DGSIDSRRRWPVFTSTEQKHVGLNTDSLKVHKGLKSQFCALWNRFLPRLLNVTENIDDAE
RQWKAEFHRWSSYMMHWKNQFDHYSKQERCTNL
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| BDBM50068306 |
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| n/a |
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| Name | BDBM50068306 |
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| Synonyms: | CHEMBL3402304 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H33N3 |
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| Mol. Mass. | 375.5496 |
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| SMILES | C(CCNC1CCN(Cc2ccccc2)CC1)CCn1ccc2ccccc12 |
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| Structure | 
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