Ki Summary

Reaction Details

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Target

Neurotensin receptor type 2

Ligand

BDBM50069088

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1466613 (CHEMBL3407206)

>10000±n/a nM

Citation

Thomas, JB; Giddings, AM; Olepu, S; Wiethe, RW; Warner, KR; Sarret, P; Longpre, JM; Runyon, SP; Gilmour, BP The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2. Bioorg Med Chem Lett25:2060-4 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neurotensin receptor type 2

Name:

Neurotensin receptor type 2

Synonyms:

Type:

PROTEIN

Mol. Mass.:

46280.50

Organism:

Rattus norvegicus

Description:

ChEMBL_1466615

Residue:

416

Sequence:

METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKA
RAGRPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAY
ATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEV
ESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALPLALTAFLNGITVNHLMALYSQV
PSASAQVSSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLR
AIVAVYVICWLPYHARRLMYCYIPDDGWTNELYDFYHYFYMVTNTLFYVSSAVTPILYNA
VSSSFRKLFLESLGSLCGEQHSLVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV

BDBM50069088

n/a

Name

BDBM50069088

Synonyms:

CHEMBL3403504

Type

Small organic molecule

Emp. Form.

C29H31ClN4O4

Mol. Mass.

535.034

SMILES

COc1cccc(OC)c1-c1cc(CN[C@@H](C2CCCCC2)C(O)=O)nn1-c1ccnc2cc(Cl)ccc12 |r,wU:15.16,(-5.51,-6.97,;-4.66,-6.08,;-5.09,-4.6,;-6.59,-4.24,;-7.02,-2.76,;-5.96,-1.65,;-4.47,-2.01,;-3.4,-.89,;-3.75,.29,;-4.03,-3.48,;-2.57,-3.96,;-2.09,-5.43,;-.55,-5.42,;.36,-6.66,;1.89,-6.5,;2.8,-7.74,;4.33,-7.57,;5.25,-8.81,;6.78,-8.64,;7.4,-7.23,;6.48,-5.99,;4.95,-6.16,;2.18,-9.15,;.96,-9.29,;2.91,-10.14,;-.08,-3.96,;-1.33,-3.08,;-1.33,-1.54,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;,.77,;1.33,1.54,;2.66,.77,;3.73,1.38,;2.66,-.77,;1.33,-1.54,;,-.77,)|

Structure