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TargetSerine protease hepsin
LigandBDBM50069104
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1466700 (CHEMBL3404298)
IC50 350±n/a nM
Citation Franco, FMJones, DEHarris, PKHan, ZWildman, SAJarvis, CMJanetka, JW Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets. Bioorg Med Chem23:2328-43 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine protease hepsin
Name:Serine protease hepsin
Synonyms:HEPS_HUMAN | HPN | Hepsin | Serine protease hepsin | TMPRSS1 | Transmembrane protease serine 11E | Transmembrane protease, serine 1
Type:Enzyme
Mol. Mass.:45016.98
Organism:Homo sapiens (Human)
Description:Human deglycosylated hepsin was expressed in Pichia pastoris.
Residue:417
Sequence:
MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD
ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV
DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL
RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH
GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ
YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE
DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
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  Blast E-value cutoff:
BDBM50069104
n/a
NameBDBM50069104
Synonyms:CHEMBL1449583 | US9182402, 4
TypeSmall organic molecule
Emp. Form.C18H16N2
Mol. Mass.260.333
SMILESCc1cccc(c1)C1Nc2cccc3cccc(N1)c23
Structure
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