| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease hepsin |
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| Ligand | BDBM50069114 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1466699 (CHEMBL3404297) |
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| Ki | 4700±n/a nM |
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| Citation |  Franco, FM; Jones, DE; Harris, PK; Han, Z; Wildman, SA; Jarvis, CM; Janetka, JW Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets. Bioorg Med Chem23:2328-43 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease hepsin |
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| Name: | Serine protease hepsin |
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| Synonyms: | HEPS_HUMAN | HPN | Hepsin | Serine protease hepsin | TMPRSS1 | Transmembrane protease serine 11E | Transmembrane protease, serine 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 45016.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human deglycosylated hepsin was expressed in Pichia pastoris. |
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| Residue: | 417 |
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| Sequence: | MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD
ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV
DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL
RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH
GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ
YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE
DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
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| BDBM50069114 |
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| n/a |
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| Name | BDBM50069114 |
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| Synonyms: | CHEMBL3403532 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H32N4O3S |
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| Mol. Mass. | 504.644 |
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| SMILES | Cc1ccc(cc1)S(=O)(=O)N[C@@H](Cc1cccc(c1)C(N)=N)C(=O)N1CCC(CC1)c1ccccc1 |r| |
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| Structure | 
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