Reaction Details |
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Target | Serine protease hepsin |
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Ligand | BDBM50063698 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1466699 (CHEMBL3404297) |
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Ki | 0.530000±n/a nM |
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Citation | Franco, FM; Jones, DE; Harris, PK; Han, Z; Wildman, SA; Jarvis, CM; Janetka, JW Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets. Bioorg Med Chem23:2328-43 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine protease hepsin |
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Name: | Serine protease hepsin |
Synonyms: | HEPS_HUMAN | HPN | Hepsin | Serine protease hepsin | TMPRSS1 | Transmembrane protease serine 11E | Transmembrane protease, serine 1 |
Type: | Enzyme |
Mol. Mass.: | 45016.98 |
Organism: | Homo sapiens (Human) |
Description: | Human deglycosylated hepsin was expressed in Pichia pastoris. |
Residue: | 417 |
Sequence: | MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD
ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV
DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL
RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH
GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ
YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE
DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
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BDBM50063698 |
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n/a |
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Name | BDBM50063698 |
Synonyms: | 4-Guanidino-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester | 4-Guanidino-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester(FUT-175) | CHEMBL273264 | Nafamostat |
Type | Small organic molecule |
Emp. Form. | C19H17N5O2 |
Mol. Mass. | 347.3706 |
SMILES | [#7]\[#6](-[#7])=[#7]/c1ccc(cc1)-[#6](=O)-[#8]-c1ccc2cc(ccc2c1)-[#6](-[#7])=[#7] |
Structure |
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