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TargetHepatocyte growth factor activator
LigandBDBM50069122
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1466697
Ki 22200±n/a nM
Citation Franco FMJones DEHarris PKHan ZWildman SAJarvis CMJanetka JW Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets. Bioorg Med Chem 23:2328-43 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hepatocyte growth factor activator
Name:Hepatocyte growth factor activator
Synonyms:HGF activator | HGFA | HGFAC | Hepatocyte growth factor activator | Hepatocyte growth factor activator long chain | Hepatocyte growth factor activator short chain
Type:PROTEIN
Mol. Mass.:70690.18
Organism:Homo sapiens (Human)
Description:ChEMBL_109514
Residue:655
Sequence:
MGRWAWVPSPWPPPGLGPFLLLLLLLLLLPRGFQPQPGGNRTESPEPNATATPAIPTILV
TSVTSETPATSAPEAEGPQSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRMLH
ACTSEGSAHRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQD
PQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGT
RHTACLSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVAST
SASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWE
YCRLEACESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHP
WLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIE
KYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGW
GHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGG
PLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50069122
n/a
NameBDBM50069122
Synonyms:CHEMBL3402440
TypeSmall organic molecule
Emp. Form.C35H47N5O3S
Mol. Mass.617.844
SMILESCC(C)c1cc(C(C)C)c(c(c1)C(C)C)S(=O)(=O)N[C@@H](Cc1cccc(c1)C(N)=N)C(=O)N1CCN(CC1)c1ccccc1 |r|
Structure
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