| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 8 |
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| Ligand | BDBM50070953 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1468800 (CHEMBL3411810) |
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| IC50 | 1740±n/a nM |
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| Citation |  Hu, H; Owens, EA; Su, H; Yan, L; Levitz, A; Zhao, X; Henary, M; Zheng, YG Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: synthesis and biological evaluation. J Med Chem58:1228-43 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 8 |
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| Name: | Protein arginine N-methyltransferase 8 |
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| Synonyms: | ANM8_HUMAN | HRMT1L3 | HRMT1L3 | HRMT1L4 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 | PRMT8 | Protein arginine N-methyltransferase 8 | Protein arginine N-methyltransferase 8 (PRMT8) | Protein arginine methyltransferase 8 (PRMT8) |
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| Type: | Protein |
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| Mol. Mass.: | 45293.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 394 |
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| Sequence: | MGMKHSSRCLLLRRKMAENAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGK
MSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGS
GTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVD
IIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWE
NVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQR
NDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISM
KPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR
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| BDBM50070953 |
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| n/a |
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| Name | BDBM50070953 |
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| Synonyms: | CHEMBL3409550 |
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| Type | Small organic molecule |
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| Emp. Form. | C49H49BrN2 |
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| Mol. Mass. | 745.831 |
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| SMILES | [Br-].CC1(C)\C(=C/C=C/C2=[N+](CCCc3ccccc3)c3ccc4ccccc4c3C2(C)C)N(CCCc2ccccc2)c2ccc3ccccc3c12 |c:7| |
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| Structure | 
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