| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 1 [11-371] |
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| Ligand | BDBM50070951 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1468798 (CHEMBL3411808) |
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| IC50 | 3050±n/a nM |
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| Citation |  Hu, H; Owens, EA; Su, H; Yan, L; Levitz, A; Zhao, X; Henary, M; Zheng, YG Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: synthesis and biological evaluation. J Med Chem58:1228-43 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 1 [11-371] |
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| Name: | Protein arginine N-methyltransferase 1 [11-371] |
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| Synonyms: | ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1 |
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| Type: | Protein |
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| Mol. Mass.: | 41506.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99873[11-371] |
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| Residue: | 361 |
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| Sequence: | MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDE
VRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIV
KANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGL
IFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNAC
LIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYT
HWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRM
R
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| BDBM50070951 |
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| n/a |
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| Name | BDBM50070951 |
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| Synonyms: | CHEMBL3409558 |
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| Type | Small organic molecule |
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| Emp. Form. | C43H37IN2S2 |
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| Mol. Mass. | 772.802 |
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| SMILES | [I-].C(CN1\C(Sc2c1ccc1ccccc21)=C\C=C\c1sc2c(ccc3ccccc23)[n+]1CCCc1ccccc1)Cc1ccccc1 |
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| Structure | 
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