| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 3 |
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| Ligand | BDBM50365463 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1469308 |
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| IC50 | 400±n/a nM |
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| Citation |  Zhao L; Wang Y; Cao D; Chen T; Wang Q; Li Y; Xu Y; Zhang N; Wang X; Chen D; Chen L; Chen YL; Xia G; Shi Z; Liu YC; Lin Y; Miao Z; Shen J; Xiong B Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization. J Med Chem 58:1281-97 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 3 |
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| Name: | Bromodomain-containing protein 3 |
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| Synonyms: | Bromodomain-containing protein 3 | Bromodomain-containing protein 3 (BRD3) | RING3-like protein |
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| Type: | Protein |
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| Mol. Mass.: | 79571.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15059 |
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| Residue: | 726 |
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| Sequence: | MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
DSSDSE
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| BDBM50365463 |
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| n/a |
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| Name | BDBM50365463 |
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| Synonyms: | CHEMBL1232461 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22ClN5O2 |
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| Mol. Mass. | 423.895 |
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| SMILES | CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc12 |r,t:7| |
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| Structure | 
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