| Reaction Details |
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 | Report a problem with these data |
| Target | Pantothenate kinase 2, mitochondrial |
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| Ligand | BDBM50071456 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1469794 (CHEMBL3413788) |
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| IC50 | 92±n/a nM |
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| Citation |  Sharma, LK; Leonardi, R; Lin, W; Boyd, VA; Goktug, A; Shelat, AA; Chen, T; Jackowski, S; Rock, CO A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases. J Med Chem58:1563-8 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pantothenate kinase 2, mitochondrial |
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| Name: | Pantothenate kinase 2, mitochondrial |
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| Synonyms: | C20orf48 | PANK2 | PANK2_HUMAN | Pantothenate kinase 2, mitochondrial | Pantothenic acid kinase 2 | hPanK2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62702.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109586 |
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| Residue: | 570 |
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| Sequence: | MRRLGPFHPRVHWAAPPSLSSGLHRLLFLRGTRIPSSTTLSPPRHDSLSLDGGTVNPPRV
REPTGREAFGPSPASSDWLPARWRNGRGGRPRARLCSGWTAAEEARRNPTLGGLLGRQRL
LLRMGGGRLGAPMERHGRASATSVSSAGEQAAGDPEGRRQEPLRRRASSASVPAVGASAE
GTRRDRLGSYSGPTSVSRQRVESLRKKRPLFPWFGLDIGGTLVKLVYFEPKDITAEEEEE
EVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIRFPTHDMPAFIQMGR
DKNFSSLHTVFCATGGGAYKFEQDFLTIGDLQLCKLDELDCLIKGILYIDSVGFNGRSQC
YYFENPADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFFG
LCCLLTGCTTFEEALEMASRGDSTKVDKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEK
REAVSKEDLARATLITITNNIGSIARMCALNENINQVVFVGNFLRINTIAMRLLAYALDY
WSKGQLKALFSEHEGYFGAVGALLELLKIP
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| BDBM50071456 |
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| n/a |
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| Name | BDBM50071456 |
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| Synonyms: | CHEMBL3410246 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N5OS |
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| Mol. Mass. | 391.489 |
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| SMILES | CSc1cccc(NC(=O)CCc2c(C)nc3c4cccnc4nn3c2C)c1 |
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| Structure | 
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