| Reaction Details |
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 | Report a problem with these data |
| Target | Baculoviral IAP repeat-containing protein 2 |
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| Ligand | BDBM50071851 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1467261 (CHEMBL3411458) |
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| IC50 | 17±n/a nM |
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| Citation |  Perez, HL; Chaudhry, C; Emanuel, SL; Fanslau, C; Fargnoli, J; Gan, J; Kim, KS; Lei, M; Naglich, JG; Traeger, SC; Vuppugalla, R; Wei, DD; Vite, GD; Talbott, RL; Borzilleri, RM Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity. J Med Chem58:1556-62 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Baculoviral IAP repeat-containing protein 2 |
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| Name: | Baculoviral IAP repeat-containing protein 2 |
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| Synonyms: | API1 | BIRC2 | BIRC2_HUMAN | Baculoviral IAP repeat-containing protein 2 (cIAP1) | Cellular inhibitor of apoptosis 1 | Inhibitor of apoptosis protein 2 (cIAP1) | MIHB | RNF48 |
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| Type: | Protein |
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| Mol. Mass.: | 69900.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13490 |
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| Residue: | 618 |
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| Sequence: | MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGV
PVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSAS
LGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYA
MSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEH
RRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGR
NDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLL
STSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTT
GENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILD
NLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLF
VDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLR
KCPICRGIIKGTVRTFLS
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| BDBM50071851 |
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| n/a |
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| Name | BDBM50071851 |
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| Synonyms: | CHEMBL3410809 |
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| Type | Small organic molecule |
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| Emp. Form. | C60H78F6N10O8 |
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| Mol. Mass. | 1181.3139 |
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| SMILES | CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)C(F)(F)C(F)(F)C(F)(F)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C |r| |
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| Structure | 
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