| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase B-raf |
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| Ligand | BDBM50072072 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1467745 (CHEMBL3412171) |
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| IC50 | 8.0±n/a nM |
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| Citation |  Smith, AL; Andrews, KL; Beckmann, H; Bellon, SF; Beltran, PJ; Booker, S; Chen, H; Chung, YA; D'Angelo, ND; Dao, J; Dellamaggiore, KR; Jaeckel, P; Kendall, R; Labitzke, K; Long, AM; Materna-Reichelt, S; Mitchell, P; Norman, MH; Powers, D; Rose, M; Shaffer, PL; Wu, MM; Lipford, JR Discovery of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK). J Med Chem58:1426-41 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase B-raf |
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| Name: | Serine/threonine-protein kinase B-raf |
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| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 84446.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15056 |
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| Residue: | 766 |
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| Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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| BDBM50072072 |
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| n/a |
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| Name | BDBM50072072 |
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| Synonyms: | CHEMBL3407849 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H27N5O3 |
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| Mol. Mass. | 541.5992 |
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| SMILES | CNc1ncc2ccc(Oc3cc(ccc3C)C(=O)c3c(-c4ccccc4)n(C)n(-c4ccccc4)c3=O)cc2n1 |
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| Structure | 
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